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Article

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.

The EMBO journal - 24 Nov 2004

Rui Yanning, Xu Zhen, Lin Shuyong, Li Qinxi, Rui Hongliang, Luo Wen, Zhou Hai-Meng, Cheung Po-Yan, Wu Zhenguo, Ye Zhiyun, Li Peng, Han Jiahuai, Lin Sheng-Cai

Abstract excerpt

Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development. We show that Axin interacts with homeodomain-interacting protein kinase-2 (HIPK2), which is linked to UV-induced p53-dependent apoptosis by interacting with, and phosphorylating Ser 46 of, p53. In addition to association with p53 via HIPK2, Axin contains a separate domain that directly interacts with p53 at their...

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Identifiers

PMID: 15526030
DOI: 10.1038/sj.emboj.7600475
PMCID: PMC533058

Genes

HIPK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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