Article
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells.
Oncogene - 8 Nov 2012
Wade M, Li Y C, Matani A S, Braun S M G, Milanesi F, Rodewald L W, Wahl G M
Abstract excerpt
Mdm2 is the major negative regulator of p53 tumor-suppressor activity. This oncoprotein is overexpressed in many human tumors that retain the wild-type p53 allele. As such, targeted inhibition of Mdm2 is being considered as a therapeutic anticancer strategy. The N-terminal hydrophobic pocket of Mdm2 binds to p53 and thereby inhibits the transcription of p53 target genes. Additionally, the C-terminus of Mdm2...
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