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Article

Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB

7 Oct 2016

Abstract excerpt

The orchestrated crosstalk between the retinoblastoma (RB) and p53 pathways contributes to preserving proper homeostasis within the cell. The deregulation of one or both pathways is a common factor in the development of most types of human cancer. The proto-oncoproteins MDMX and MDM2 are the main regulators of the wellknown tumor suppressor p53 protein. Under normal conditions, MDM2 and MDMX inhibit p53, either...

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PMID: 28050229
DOI: 10.18632/genesandcancer.120

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