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Article

Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity.

The Journal of biological chemistry - 28 Jun 2013

Ranaweera Ruchira S, Yang Xiaolu

Abstract excerpt

The RING domain E3 ubiquitin ligase Mdm2 is the master regulator of the tumor suppressor p53. It targets p53 for proteasomal degradation, restraining the potent activity of p53 and enabling cell survival and proliferation. Like most E3 ligases, Mdm2 can also ubiquitinate itself. How Mdm2 auto-ubiquitination may influence its substrate ubiquitin ligase activity is undefined. Here we show that auto-ubiquitination...

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Identifiers

PMID: 23671280
DOI: 10.1074/jbc.M113.454470
PMCID: PMC3696669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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