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Article

Mdm2 Affects Genome Stability Independent of p53

25 Feb 2009

Abstract excerpt

Mdm2 is a critical negative regulator of the p53 tumor suppressor and is frequently overexpressed in human cancers. However, reports, including our own studies, suggest that Mdm2 has both p53-dependent and p53-independent functions that contribute to genomic instability and transformation when deregulated. We recently elucidated a p53-independent role for Mdm2 in the regulation of the DNA double-strand break...

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PMID: 19244108
DOI: 10.1158/0008-5472.can-08-3732

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