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Article

Regulation of the p53 tumor suppressor pathway: the problems and promises of studying Mdm2's E3 ligase function.

Critical reviews in eukaryotic gene expression - 1 Jan 2010

Clegg Hilary V, Zhang Yanping

Abstract excerpt

Mdm2 is a major negative regulator of the tumor suppressor p53 and has long been thought to inhibit p53 in two ways: by ubiquitinating p53 to signal for its degradation, and by binding to p53, masking its transactivation domain. Mdm2 is also believed to control its own levels by autoubiquitination. Despite the widespread acceptance of these hypotheses, the supporting data were drawn primarily from in vitro and...

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Identifiers

PMID: 20528739
DOI: 10.1615/critreveukargeneexpr.v20.i1.60

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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