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Article

The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.

Oncotarget - 21 Feb 2017

Le Noir Sandrine, Laffleur Brice, Carrion Claire, Garot Armand, Lecardeur Sandrine, Pinaud Eric, Denizot Yves, Skok Jane, Cogné Michel

Abstract excerpt

Immunoglobulin heavy chain (IgH) alleles have ambivalent relationships: they feature both allelic exclusion, ensuring monoallelic expression of a single immunoglobulin (Ig) allele, and frequent inter-allelic class-switch recombination (CSR) reassembling genes from both alleles. The IgH locus 3' regulatory region (3'RR) includes several transcriptional cis-enhancers promoting activation-induced cytidine deaminase...

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Identifiers

PMID: 28088785
DOI: 10.18632/oncotarget.14585
PMCID: PMC5355067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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