Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of the Ig κ Light Chain Intronic and 3′ Enhancers in Igk Somatic Hypermutation

1 Jul 2006

Abstract excerpt

Somatic hypermutation (SHM) of the rearranged Ig genes is required for the affinity maturation of Abs. SHM is almost exclusively targeted to the rearranged Ig loci, but the mechanism of this gene-specific targeting remains unclear. The Ig kappa L chain locus contains multiple enhancers, including the MAR/intronic (iE(kappa)) and 3' enhancers (3'E(kappa)). Previous transgenic studies indicate that both kappa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16818772
DOI: 10.4049/jimmunol.177.2.1146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of the Ig κ Light Chain Intronic and 3′ Enhancers in Igk Somatic HypermutationPMID 16818772Read ↗

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cellsSemantic proximity Read ↗

The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.Semantic proximity Read ↗

Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.Semantic proximity Read ↗

The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation.Semantic proximity Read ↗

Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation.Semantic proximity Read ↗

A Multifunctional Element in the Mouse Igκ Locus That Specifies Repertoire and Ig Loci Subnuclear LocationSemantic proximity Read ↗

A class switch control region at the 3' end of the immunoglobulin heavy chain locus.Semantic proximity Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.Semantic proximity Read ↗

Epigenetic ontogeny of the Igk locus during B cell development.Semantic proximity Read ↗

Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Semantic proximity Read ↗

Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.