A class switch control region at the 3' end of the immunoglobulin heavy chain locus.

doi:10.1016/0092-8674(94)90057-4

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Article

A class switch control region at the 3' end of the immunoglobulin heavy chain locus.

Cell - 3 Jun 1994

Cogné M, Lansford R, Bottaro A, Zhang J, Gorman J, Young F, Cheng H L, Alt F W

Abstract excerpt

We replaced the IgH 3' enhancer (3'EH) region with a neomycin resistance gene in ES cells and generated chimeric mice in which all mature lymphocytes were either heterozygous (3'EH+/-) or homozygous (3'EH-/-) for the mutation. In vitro activated 3'EH-/- B cells responded similarly to 3'EH+/- B ce...

Topics

Animals
Chimera
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Genes, Switch
Heterozygote
Homozygote
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Isotypes
Mice
Mice, Transgenic
Mutation
Phenotype
Restriction Mapping
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 8205622
DOI: 10.1016/0092-8674(94)90057-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8205622-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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