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Article

Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.

The Journal of biological chemistry - 5 Aug 2011

Yan Yi, Pieretti Joyce, Ju Zhongliang, Wei Shiniu, Christin John R, Bah Fatmata, Birshtein Barbara K, Eckhardt Laurel A

Abstract excerpt

Immunoglobulin heavy chain (IgH) genes are formed, tested, and modified to yield diverse, specific, and high affinity antibody responses to antigen. The processes involved must be regulated, however, to avoid unintended damage to chromosomes. The 3' regulatory region of the Igh locus plays a major role in regulating class-switch recombination (CSR), the process by which antibody effector functions are modified...

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Identifiers

PMID: 21673112
DOI: 10.1074/jbc.M111.230995
PMCID: PMC3149305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.PMID 21673112Read ↗

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The IgH 3′ regulatory region and its implication in lymphomagenesisSemantic proximity Read ↗

Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.Semantic proximity Read ↗

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Physiological role of the 3′IgH CBEs super-anchor in antibody class switchingSemantic proximity Read ↗

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.Semantic proximity Read ↗

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cellsSemantic proximity Read ↗

Ig heavy chain expression and class switching in vitro from an allele lacking the 3' enhancers DNase I-hypersensitive hs3A and hs1,2.Semantic proximity Read ↗

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