Article
The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.
Rheumatology (Oxford, England) - 1 Nov 2013
Cauli Alberto, Shaw Jacqueline, Giles Joanna, Hatano Hiroko, Rysnik Oliwia, Payeli Sravan, McHugh Kirsty, Dessole Grazia, Porru Giovanni, Desogus Elisabetta, Fiedler Sarah, Hölper Soraya, Carette Amanda, Blanco-Gelaz Miguel Angel, Vacca Alessandra, Piga Matteo, Ibba Valentina, Garau Pietro, La Nasa Giorgio, López-Larrea Carlos, Mathieu Alessandro, Renner Christoph, Bowness Paul, Kollnberger Simon
Abstract excerpt
OBJECTIVES: HLA-B*27:05 is associated with AS whereas HLA-B*27:09 is not associated. We hypothesized that different interactions with KIR immune receptors could contribute to the difference in disease association between HLA-B*27:05 and HLAB*27:09. Thus, the objective of this study was to compare the formation of β2m-free heavy chain (FHC) including B27 dimers (B272) by HLA-B*27:05 and HLA-B*27:09 and their...
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