Article
Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.
The Journal of biological chemistry - 27 Dec 2019
Lim Kam Sian Terry C C, Indumathy Saranjah, Halim Hanim, Greule Anja, Cryle Max J, Bowness Paul, Rossjohn Jamie, Gras Stephanie, Purcell Anthony W, Schittenhelm Ralf B
Abstract excerpt
Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and other spondyloarthropathies. However, the exact involvement of HLA-B27 in disease initiation and progression remains unclear. The homodimer theory, which proposes that HLA-B27 heavy chains aberrantly form homodimers, is a central hypothesis that attempts to explain the role of HLA-B27...
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