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Article

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis.

PLoS genetics - 1 Aug 2020

Hanson Aimee L, Vukcevic Damjan, Leslie Stephen, Harris Jessica, Lê Cao Kim-Anh, Kenna Tony J, Brown Matthew A

Abstract excerpt

The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells, are a collection of highly polymorphic activating and inhibitory receptors with variable specificity for class I human leukocyte antigen (HLA) ligands. Fifteen KIR genes are inherited in haplotypes of diverse gene content across the human population, and the repertoire of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32804949
DOI: 10.1371/journal.pgen.1008906
PMCID: PMC7451988

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