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Article

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

10 Jun 2016

Abstract excerpt

Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. p53 activates NGFR transcription, whereas NGFR inactivates p53 by promoting its MDM2-mediated ubiquitin-dependent proteolysis and by directly binding to its central DNA binding domain and preventing its DNA-binding activity. Inversely, NGFR ablation activates...

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PMID: 27282385
DOI: 10.7554/elife.15099

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