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Article

TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism.

The Journal of biological chemistry - 12 Aug 2005

Lavoie Jean-François, Lesauteur Lynne, Kohn Judi, Wong Josee, Furtoss Olivia, Thiele Carol J, Miller Freda D, Kaplan David R

Abstract excerpt

Neuroblastoma (NB) is the most frequent solid extracranial tumor in children. Its clinical prognosis correlates with the expression of members of the Trk neurotrophin receptor family, which includes TrkA and TrkB. TrkA expression is associated with favorable prognosis, whereas TrkB expression is associated with poor prognosis. Here we show that TrkA expression induces the apoptosis of NB cells and does so by...

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Identifiers

PMID: 15961390
DOI: 10.1074/jbc.M502364200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism.PMID 15961390Read ↗

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