Article
The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Oct 2007
Segura Miguel F, Sole Carme, Pascual Marta, Moubarak Rana S, Perez-Garcia M Jose, Gozzelino Raffaella, Iglesias Victoria, Badiola Nahuai, Bayascas Jose R, Llecha Nuria, Rodriguez-Alvarez Jose, Soriano Eduardo, Yuste Victor J, Comella Joan X
Abstract excerpt
Death receptors (DRs) and their ligands are expressed in developing nervous system. However, neurons are generally resistant to death induction through DRs and rather their activation promotes neuronal outgrowth and branching. These results suppose the existence of DRs antagonists expressed in the nervous system. Fas apoptosis inhibitory molecule (FAIM(S)) was first identified as a Fas antagonist in B-cells. Soon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.