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Article

Dependence Receptors and Cancer: Addiction to Trophic Ligands

1 Dec 2015

Abstract excerpt

Data accumulating over the last 20 years support the notion that some transmembrane receptors are activated not only by their respective ligands but also, differentially, by the withdrawal or absence of these same ligands. In this latter setting, these receptors actively trigger apoptosis. They have been dubbed dependence receptors because their expression confers a state of ligand dependence for survival on the...

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PMID: 26627011
DOI: 10.1158/0008-5472.can-14-3652

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