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Article

Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.

Cancer research - 15 Apr 2008

Molenaar Jan J, Ebus Marli E, Koster Jan, van Sluis Peter, van Noesel Carel J M, Versteeg Rogier, Caron Huib N

Abstract excerpt

Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor. Here, we report that analysis of Affymetrix expression data of primary neuroblastic tumors shows an extensive overexpression of Cyclin D1, which correlates with histologic subgroups. Immunohistochemical analysis showed...

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Source

Identifiers

PMID: 18413728
DOI: 10.1158/0008-5472.CAN-07-5032

Genes

CDK4
CDK6
CCND1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.PMID 18413728Read ↗

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