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Article

Apoptosis initiated by dependence receptors: a new paradigm for cell death?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 2004

Porter Alan G, Dhakshinamoorthy Saravanakumar

Abstract excerpt

A distinct group of receptors including DCC, UNC5, RET and Ptc1 is known to function in ligand-dependent neuronal growth and differentiation or axon guidance. Acting as "dependence receptors", they may also regulate neuronal cell survival by inducing apoptosis in the absence of cognate ligand. Receptor-initiated apoptosis requires proteolytic (caspase) cleavage and exposure of a pro-apoptotic region in the...

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Source

Identifiers

PMID: 15170863
DOI: 10.1002/bies.20037

Genes

DCC
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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