Article
N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53.
Biochemical pharmacology - 1 Nov 2009
Janardhanan Rajiv, Banik Naren L, Ray Swapan K
Abstract excerpt
Neuroblastomas, which mostly occur in children, are aggressive metastatic tumors of the sympathetic nervous system. The failure of the previous therapeutic regimens to target multiple components of N-Myc pathway resulted in poor prognosis. The present study investigated the efficacy of the combination of N-(4-hydroxyphenyl) retinamide (4-HPR, 0.5 microM) and genistein (GST, 25 microM) to control the growth of...
Topics
- Apoptosis
- Cell Cycle
- Cell Differentiation
- Cell Line, Tumor
- Fenretinide
- Flow Cytometry
- Genes, p53
- Glutathione Transferase
- Humans
- Mutation
- Neuroblastoma