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Article

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

17 Jun 2013

Abstract excerpt

The effects of diverse stresses on promoter selectivity and transcription regulation by the tumor suppressor p53 are poorly understood. We have taken a comprehensive approach to characterizing the human p53 network that includes p53 levels, binding, expression and chromatin changes under diverse stresses. Human osteosarcoma U2OS cells treated with anti-cancer drugs Doxorubicin (DXR) or Nutlin-3 (Nutlin) led to...

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PMID: 23775793
DOI: 10.1093/nar/gkt504

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