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Transcriptional modulation induced by ionizing radiation: p53 remains a central player

7 Jul 2011

Abstract excerpt

The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double-strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation...

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PMID: 21795128
DOI: 10.1016/j.molonc.2011.06.004

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