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Article

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

26 Jun 2008

Abstract excerpt

Sequence-specific binding by the human p53 master regulator is critical to its tumor suppressor activity in response to environmental stresses. p53 binds as a tetramer to two decameric half-sites separated by 0-13 nucleotides (nt), originally defined by the consensus RRRCWWGYYY (n = 0-13) RRRCWWGYYY. To better understand the role of sequence, organization, and level of p53 on transactivation at target response...

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PMID: 18714371
DOI: 10.1371/journal.pgen.1000104

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