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Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics

12 Apr 2013

Abstract excerpt

Estrogen receptors (ERs) and p53 can interact via cis-elements to regulate the angiogenesis-related VEGFR-1 (FLT1) gene, as we reported previously. Here, we address cooperation between these transcription factors on a global scale. Human breast adenocarcinoma MCF7 cells were exposed to single or combinatorial treatments with the chemotherapeutic agent doxorubicin and the ER ligand 17β-estradiol (E2). Whole-genome...

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PMID: 23518503
DOI: 10.4161/cc.24309

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