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Article

Genome-wide analysis of p53 under hypoxic conditions.

Molecular and cellular biology - 1 May 2006

Hammond Ester M, Mandell Daniel J, Salim Ali, Krieg Adam J, Johnson Thomas M, Shirazi Haider A, Attardi Laura D, Giaccia Amato J

Abstract excerpt

Hypoxia is an important nongenotoxic stress that modulates the tumor suppressor activity of p53 during malignant progression. In this study, we investigated how genotoxic and nongenotoxic stresses regulate p53 association with chromatin, p53 transcriptional activity, and p53-dependent apoptosis. We found that genotoxic and nongenotoxic stresses result in the accumulation and binding of the p53 tumor suppressor...

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Source

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Identifiers

PMID: 16611991
DOI: 10.1128/MCB.26.9.3492-3504.2006
PMCID: PMC1447427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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