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Identification of new p53 target microRNAs by bioinformatics and functional analysis

21 Nov 2013

Abstract excerpt

BACKGROUND: The tumor suppressor p53 is a sequence-specific transcription factor that regulates an extensive network of coding genes, long non-coding RNAs and microRNAs, that establish intricate gene regulatory circuits influencing many cellular responses beyond the prototypical control of cell cycle, apoptosis and DNA repair. METHODS: Using bioinformatic approaches, we identified an additional group of candidate...

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PMID: 24256616
DOI: 10.1186/1471-2407-13-552

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