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Differential p53-Mediated Cellular Responses to DNA-Damaging Therapeutic Agents

31 Oct 2021

Abstract excerpt

, which encodes the tumor suppressor protein p53, is mutated in about 50% of cancers. In response to cell stressors like DNA damage and after treatment with DNA-damaging therapeutic agents, p53 acts as a transcription factor to activate subsets of target genes which carry out cell fates such as apoptosis, cell cycle arrest, and DNA repair. Target gene selection by p53 is controlled by a complex regulatory network...

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PMID: 34769259
DOI: 10.3390/ijms222111828

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