Article

Comparison of genotoxic vs. non-genotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks

2018-07-03

Abstract excerpt

The tumor suppressor protein p53 is activated in response to diverse intrinsic and extrinsic cellular stresses and controls a broad cell-protective gene network. Whether p53:DNA binding and subsequent transcriptional activation differs downstream of these diverse intrinsic and extrinsic activators within the same cell type is controversial. Using primary human fibroblasts, we assessed the genome-wide profile of p5...

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Literature Corpus work: d96afdea-10f0-5db6-a523-1de0aaa93b7b
DOI: 10.1101/360974

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