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Article

CDK5-cyclin B1 regulates mitotic fidelity.

Nature - 1 Sept 2024

Zheng Xiao-Feng, Sarkar Aniruddha, Lotana Humphrey, Syed Aleem, Nguyen Huy, Ivey Richard G, Kennedy Jacob J, Whiteaker Jeffrey R, Tomasik Bartłomiej, Huang Kaimeng, Li Feng, D'Andrea Alan D, Paulovich Amanda G, Shah Kavita, Spektor Alexander, Chowdhury Dipanjan

Abstract excerpt

CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392. Here, using independent chemical genetic approaches, we...

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Mitosis
Multiprotein Complexes
Phosphoproteins
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CDC2 Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cyclin-Dependent Kinase 5

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Identifiers

PMID: 39232161
DOI: 10.1038/s41586-024-07888-x
PMCID: PMC12307448

Genes

CDK5
CDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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