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Article

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

27 May 2009

Abstract excerpt

Polo-like kinases (PLKs) are a group of highly conserved serine/threonine protein kinases that play a key role in processes such as cell division and checkpoint regulation of mitosis. About 80% of human tumors, of various origins, express high levels of PLK transcripts. However, PLK mRNA is mostly absent in surrounding healthy tissues. Overexpression of PLK is associated with a poor prognosis in several tumor...

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PMID: 19474163
DOI: 10.1634/theoncologist.2009-0010

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