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Article

Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2011

Ratsima Hery, Ladouceur Anne-Marie, Pascariu Mirela, Sauvé Véronique, Salloum Zeina, Maddox Paul S, D'Amours Damien

Abstract excerpt

Polo-like kinases (PLKs) are evolutionarily conserved kinases essential for cell cycle regulation. These kinases are characterized by the presence of a C-terminal phosphopeptide-interaction domain, the polo-box domain (PBD). How the functional domains of PLKs work together to promote cell division is not understood. To address this, we performed a genetic screen to identify mutations that independently modulate...

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Identifiers

PMID: 21987786
DOI: 10.1073/pnas.1106448108
PMCID: PMC3203808

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Source receipt: pubmed, retrieved 7 Sept 2026.

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