Article
Genome-wide survey of protein kinases required for cell cycle progression.
Nature - 23 Dec 2004
Bettencourt-Dias M, Giet R, Sinka R, Mazumdar A, Lock W G, Balloux F, Zafiropoulos P J, Yamaguchi S, Winter S, Carthew R W, Cooper M, Jones D, Frenz L, Glover D M
Abstract excerpt
Cycles of protein phosphorylation are fundamental in regulating the progression of the eukaryotic cell through its division cycle. Here we test the complement of Drosophila protein kinases (kinome) for cell cycle functions after gene silencing by RNA-mediated interference. We observed cell cycle dysfunction upon downregulation of 80 out of 228 protein kinases, including most kinases that are known to regulate the...
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