Article
Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Hayashi Aki, Ishida Mayumi, Kawaguchi Rika, Urano Takeshi, Murakami Yota, Nakayama Jun-ichi
Abstract excerpt
In fission yeast, the RNAi pathway is required for centromeric heterochromatin assembly. siRNAs derived from centromeric transcripts are incorporated into the RNA-induced transcriptional silencing (RITS) complex and direct it to nascent homologous transcripts. The RNA-induced transcriptional silencing-bound nascent transcripts further recruit the RNA-directed RNA polymerase complex (RDRC) to promote dsRNA...
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