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Article

Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs.

Journal of the American Heart Association - 26 Jan 2015

Hiltunen Timo P, Donner Kati M, Sarin Antti-Pekka, Saarela Janna, Ripatti Samuli, Chapman Arlene B, Gums John G, Gong Yan, Cooper-DeHoff Rhonda M, Frau Francesca, Glorioso Valeria, Zaninello Roberta, Salvi Erika, Glorioso Nicola, Boerwinkle Eric, Turner Stephen T, Johnson Julie A, Kontula Kimmo K

Abstract excerpt

BACKGROUND: Identification of genetic markers of antihypertensive drug responses could assist in individualization of hypertension treatment. METHODS AND RESULTS: We conducted a genome-wide association study to identify gene loci influencing the responsiveness of 228 male patients to 4 classes of antihypertensive drugs. The Genetics of Drug Responsiveness in Essential Hypertension (GENRES) study is a...

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Source

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Identifiers

PMID: 25622599
DOI: 10.1161/JAHA.115.001778
PMCID: PMC4330076

Genes

ACY3
CLIC5
NPHS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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