Article
A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2016
Shahin Mohamed H, Gong Yan, McDonough Caitrin W, Rotroff Daniel M, Beitelshees Amber L, Garrett Timothy J, Gums John G, Motsinger-Reif Alison, Chapman Arlene B, Turner Stephen T, Boerwinkle Eric, Frye Reginald F, Fiehn Oliver, Cooper-DeHoff Rhonda M, Kaddurah-Daouk Rima, Johnson Julie A
Abstract excerpt
Hydrochlorothiazide is among the most commonly prescribed antihypertensives; yet, <50% of hydrochlorothiazide-treated patients achieve blood pressure (BP) control. Herein, we integrated metabolomic and genomic profiles of hydrochlorothiazide-treated patients to identify novel genetic markers associated with hydrochlorothiazide BP response. The primary analysis included 228 white hypertensives treated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.