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Article

Functional characterization of 20 allelic variants of CYP1A2.

Drug metabolism and pharmacokinetics - 1 Jun 2015

Ito Miyabi, Katono Yuki, Oda Akifumi, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Genetic variations in cytochrome P450 1A2 (CYP1A2) are associated with interindividual variability in the metabolism and efficacy of many medications. Twenty CYP1A2 variants harboring amino acid substitutions were analyzed for functional changes in enzymatic activity. Recombinant CYP1A2 variant proteins were heterologously expressed in COS-7 cells. Enzyme kinetic analyses were performed with two representative...

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Identifiers

PMID: 26022657
DOI: 10.1016/j.dmpk.2015.03.001

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