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Article

A fight for neurotransmission: SCRAPPER trashes RIM.

Cell - 7 Sept 2007

Dobie Frederick, Craig Ann Marie

Abstract excerpt

The presynaptic scaffold molecule RIM1alpha is important for regulating neurotransmitter release. In this issue, Yao et al. (2007) show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1alpha for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check.

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Identifiers

PMID: 17803899
DOI: 10.1016/j.cell.2007.08.020
PMCID: PMC2821330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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