Article
Independent regulation of synaptic size and activity by the anaphase-promoting complex.
Cell - 24 Nov 2004
van Roessel Peter, Elliott David A, Robinson Iain M, Prokop Andreas, Brand Andrea H
Abstract excerpt
Neuronal plasticity relies on tightly regulated control of protein levels at synapses. One mechanism to control protein abundance is the ubiquitin-proteasome degradation system. Recent studies have implicated ubiquitin-mediated protein degradation in synaptic development, function, and plasticity, but little is known about the regulatory mechanisms controlling ubiquitylation in neurons. In contrast,...
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