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Article

SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.

Cell - 7 Sept 2007

Yao Ikuko, Takagi Hiroshi, Ageta Hiroshi, Kahyo Tomoaki, Sato Showbu, Hatanaka Ken, Fukuda Yoshiyuki, Chiba Tomoki, Morone Nobuhiro, Yuasa Shigeki, Inokuchi Kaoru, Ohtsuka Toshihisa, Macgregor Grant R, Tanaka Keiji, Setou Mitsutoshi

Abstract excerpt

Little is known about how synaptic activity is modulated in the central nervous system. We have identified SCRAPPER, a synapse-localized E3 ubiquitin ligase, which regulates neural transmission. SCRAPPER directly binds and ubiquitinates RIM1, a modulator of presynaptic plasticity. In neurons from Scrapper-knockout (SCR-KO) mice, RIM1 had a longer half-life with significant reduction in ubiquitination, indicating...

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Identifiers

PMID: 17803915
DOI: 10.1016/j.cell.2007.06.052
PMCID: PMC3049808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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