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RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

10 Jun 2013

Abstract excerpt

Protein modifications by ubiquitin and small ubiquitin-like modifier (SUMO) play key roles in cellular signaling pathways. SUMO-targeted ubiquitin ligases (STUbLs) directly couple these modifications by selectively recognizing SUMOylated target proteins through SUMO-interacting motifs (SIMs), promoting their K48-linked ubiquitylation and degradation. Only a single mammalian STUbL, RNF4, has been identified. We...

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PMID: 23751493
DOI: 10.1083/jcb.201212075

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