Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUMO-targeted ubiquitin ligases in genome stability.

The EMBO journal - 19 Sept 2007

Prudden John, Pebernard Stephanie, Raffa Grazia, Slavin Daniela A, Perry J Jefferson P, Tainer John A, McGowan Clare H, Boddy Michael N

Abstract excerpt

We identify the SUMO-Targeted Ubiquitin Ligase (STUbL) family of proteins and propose that STUbLs selectively ubiquitinate sumoylated proteins and proteins that contain SUMO-like domains (SLDs). STUbL recruitment to sumoylated/SLD proteins is mediated by tandem SUMO interaction motifs (SIMs) with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomic Instability
Share to Homeostasis
Share to Microbial Viability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagens

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Small Ubiquitin-Related Modifier Proteins

Share to Ubiquitin-Conjugating Enzymes

Source

Open in PubMed Open full text

Identifiers

PMID: 17762865
DOI: 10.1038/sj.emboj.7601838
PMCID: PMC2230673

Genes

RNF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17762865-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMO-targeted ubiquitin ligases in genome stability.PMID 17762865Read ↗

Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligasesSemantic proximity Read ↗

Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response.Semantic proximity Read ↗

RNF4—A Paradigm for SUMOylation‐Mediated UbiquitinationSemantic proximity Read ↗

Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.Semantic proximity Read ↗

Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.Semantic proximity Read ↗

Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeastSemantic proximity Read ↗

Role of SUMO in the dynamics of telomere maintenance in fission yeast.Semantic proximity Read ↗

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferationSemantic proximity Read ↗

DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.Semantic proximity Read ↗

Genome stability roles of SUMO-targeted ubiquitin ligasesSemantic proximity Read ↗

RNF4 is required for DNA double-strand break repair in vivo.Semantic proximity Read ↗

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.