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Article

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.

Scientific reports - 4 Jun 2015

Akita Masaki, Tak Yon-Soo, Shimura Tsutomu, Matsumoto Syota, Okuda-Shimizu Yuki, Shimizu Yuichiro, Nishi Ryotaro, Saitoh Hisato, Iwai Shigenori, Mori Toshio, Ikura Tsuyoshi, Sakai Wataru, Hanaoka Fumio, Sugasawa Kaoru

Abstract excerpt

The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation i...

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Source

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Identifiers

PMID: 26042670
DOI: 10.1038/srep10984
PMCID: PMC4455304

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26042670-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.PMID 26042670Read ↗

Overview of xeroderma pigmentosum proteins architecture, mutations and post-translational modifications.Semantic proximity Read ↗

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The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.Semantic proximity Read ↗

Revisiting the structural features of the xeroderma pigmentosum proteins: Focus on mutations and knowledge gaps.Semantic proximity Read ↗

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