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Article

DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.

Molecular and cellular biology - 1 Jun 2011

Prudden John, Perry J Jefferson P, Nie Minghua, Vashisht Ajay A, Arvai Andrew S, Hitomi Chiharu, Guenther Grant, Wohlschlegel James A, Tainer John A, Boddy Michael N

Abstract excerpt

Global sumoylation, SUMO chain formation, and genome stabilization are all outputs generated by a limited repertoire of enzymes. Mechanisms driving selectivity for each of these processes are largely uncharacterized. Here, through crystallographic analyses we show that the SUMO E2 Ubc9 forms a noncovalent complex with a SUMO-like domain of Rad60 (SLD2). Ubc9:SLD2 and Ubc9:SUMO noncovalent complexes are...

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Identifiers

PMID: 21444718
DOI: 10.1128/MCB.05188-11
PMCID: PMC3133251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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