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Article

Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases

23 Oct 2023

Abstract excerpt

Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and subsequently ubiquitinate them via the RING domain, thereby bridging the SUMO and ubiquitin signaling pathways. STUbLs participate in a wide array of molecular processes,...

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PMID: 38047137
DOI: 10.1016/j.cellin.2023.100128

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