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Article

RNF4—A Paradigm for SUMOylation‐Mediated Ubiquitination

1 Oct 2019

Abstract excerpt

Covalent modifications by Small Ubiquitin-like MOdifier (SUMO) and ubiquitin conjugation are now recognized as independent posttranslational modifications (PTMs) employed by cells to reversibly regulate cellular signaling. SUMOylation in particular has emerged as a crucial cellular mechanism involved in multiple pathologies, including cancers, cardiovascular diseases, immunological and neurological disorders, as...

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PMID: 31566917
DOI: 10.1002/pmic.201900185

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