Article
RNF4 is required for DNA double-strand break repair in vivo.
Cell death and differentiation - 1 Mar 2013
Vyas R, Kumar R, Clermont F, Helfricht A, Kalev P, Sotiropoulou P, Hendriks I A, Radaelli E, Hochepied T, Blanpain C, Sablina A, van Attikum H, Olsen J V, Jochemsen A G, Vertegaal A C O, Marine J-C
Abstract excerpt
Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signaling and repair proteins to the sites of DNA lesions. Coordinated protein SUMOylation and ubiquitylation have crucial roles in regulating the dynamic assembly of protein complexes at these sites. However, how SUMOylation influences...
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