The rate of spontaneous mutations in human myeloid cells.

Abstract excerpt

The mutation rate (μ) is likely to be a key parameter in leukemogenesis, but historically, it has been difficult to measure in humans. The PIG-A gene has some advantages for the detection of spontaneous mutations because it is X-linked, and therefore only one mutation is required to disrupt its function. Furthermore, the PIG-A-null phenotype is readily detected by flow cytometry. Using PIG-A, we have now provided...

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• Share to Mutation Rate
• Share to Myeloid Cells
• Share to Core Binding Factor Alpha 2 Subunit