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Article

Leukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia.

The American journal of pathology - 1 Nov 2012

Araten David J, Sanders Katie J, Anscher Dan, Zamechek Leah, Hunger Stephen P, Ibrahim Sherif

Abstract excerpt

It has been proposed that genomic instability is essential to account for the multiplicity of mutations often seen in malignancies. Using the X-linked PIG-A gene as a sentinel gene for spontaneous inactivating somatic mutations, we previously showed that healthy individuals harbor granulocytes with the PIG-A mutant (paroxysmal nocturnal hemoglobinuria) phenotype at a median frequency (f) of ∼12 × 10(-6). Herein,...

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Identifiers

PMID: 22940070
DOI: 10.1016/j.ajpath.2012.07.025
PMCID: PMC3483812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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