Article
The rate of mutation of a single gene.
Nucleic acids research - 1 Mar 2010
Balin Samuel J, Cascalho Marilia
Abstract excerpt
The rate of mutation refers to the probability that a unit length of DNA (generally a base pair) mutates with time. Fluctuation analysis or mutant accumulation assays applied to phenotypic changes measure mutation rates of cells. However, only a few phenotypic changes indicative of mutations are known thus limiting the analysis to those rare genes. Direct sequencing overcomes the limitations imposed by phenotypic...
Topics
- Animals
- Cell Line
- Clone Cells
- Genes
- Mice
- Mutation
- Sequence Analysis, DNA
- env Gene Products, Human Immunodeficiency Virus