A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene.

doi:10.1016/j.mrfmmm.2009.11.012

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Article

A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene.

Mutation research - 1 Apr 2010

Araten David J, Martinez-Climent Jose A, Perle Mary Ann, Holm Eliana, Zamechek Leah, DiTata Kimberly, Sanders Katie J

Abstract excerpt

It has been proposed that hypermutability is necessary to account for the high frequency of mutations in cancer. However, historically, the mutation rate (mu) has been difficult to measure directly, and increased cell turnover or selection could provide an alternative explanation. We recently developed an assay for mu using PIG-A as a sentinel gene and estimated that its average value is 10.6 x 10(-7) mutations...

Topics

Cell Line, Tumor
Clone Cells
Flow Cytometry
Genomic Instability
Humans
Leukemia, T-Cell
Lymphoma
Membrane Proteins
Mutation
Neoplasms, Plasma Cell

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Identifiers

PMID: 20060400
DOI: 10.1016/j.mrfmmm.2009.11.012
PMCID: PMC2834866

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